歐盟專家組審查了現(xiàn)有的文獻(xiàn)認(rèn)為，無足夠證據(jù)支持河豚毒素最小致死劑量為2毫克的結(jié)論，部分人攝取僅0.2毫克，相當(dāng)于4微克/千克體重，即可出現(xiàn)嚴(yán)重癥狀。

 

    經(jīng)過風(fēng)險(xiǎn)評(píng)估，歐盟食品安全局認(rèn)為，貝肉濃度低于44微克當(dāng)量TTX / kg不會(huì)對(duì)人體產(chǎn)生不利影響。液相色譜串聯(lián)質(zhì)譜法（LC-MS / MS）最適合檢測河豚毒素及其類似物，定量限為0.1-25微克/千克。

 

    部分原文報(bào)道如下：

 

    Tetrodotoxin （TTX） and its analog ues are produced by marine bacteria and have been dete cted inmarine bivalves and gastropods from European waters. The European Commission asked EFSA for ascienti?c opinion on the risks to public health related to the presence of TTX and TTX analogues inmarine bivalves and gastropods. The Panel on Contaminants in the Food Chain reviewed the availableliterature but did not ?nd support for the minimum lethal dose for humans of 2 mg, mentioned invarious reviews. Some human case reports describe serious effects at a dose of 0.2 mg, correspondingto 4 lg/kg body weight （bw）。