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    歐盟評估谷氨酸棒桿菌KCCM 80389生產(chǎn)的L-組氨酸和L-組氨酸鹽酸鹽-水合物作為所有動物飼料添加劑的安全性和有效性
    日期:2025-08-01  來源:食品伙伴網(wǎng)
       食品伙伴網(wǎng)訊  2025年7月30日,據(jù)歐盟食品安全局EFSA)消息,應(yīng)歐盟委員會要求,歐盟動物飼料添加劑和產(chǎn)品(FEEDAP)研究小組就谷氨酸棒桿菌KCCM 80389發(fā)酵生產(chǎn)的L-組氨酸和L-組氨酸鹽酸鹽-水合物(l-histidine monohydrochloride monohydrate)作為所有動物飼料添加劑的安全性和有效性發(fā)表科學(xué)意見。
     
      經(jīng)過評估,專家小組認(rèn)為該添加劑對目標(biāo)物種、消費(fèi)者和環(huán)境是安全的。評估中的添加劑被認(rèn)為是所有非反芻動物物種氨基酸L-組氨酸的有效來源。為了使補(bǔ)充的L-組氨酸對反芻動物和非反芻動物同樣有效,需要防止其在瘤胃中降解。部分原文報道如下:
     
      Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-histidine and l-histidine monohydrochloride monohydrate produced with a genetically modified strain of Corynebacterium glutamicum (KCCM 80389) as nutritional and sensory feed additives for all animal species and categories. l-Histidine and l-histidine monohydrochloride monohydrate manufactured by fermentation with C. glutamicum KCCM 80389 do not give rise to any safety concern regarding the genetic modifications of the production strain. No viable cells or DNA of the production strain were detected in the final products. The FEEDAP Panel concluded that the use of l-histidine and l-histidine monohydrochloride monohydrate produced with C. glutamicum KCCM 80389 in feed raises no safety concerns for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the species. The FEEDAP Panel had concerns on the use of l-histidine and l-histidine monohydrochloride monohydrate in water for drinking. The FEEDAP Panel concluded that the use of l-histidine and l-histidine monohydrochloride monohydrate produced by fermentation with C. glutamicum KCCM 80389 in animal nutrition are safe for the consumers of products from animals receiving the additive, and to the environment. Regarding the user safety, the additives are not considered irritant to skin or eyes and are not considered potential skin sensitisers. The additives were regarded as effective sources of the amino acid l-histidine for all non-ruminant species. To be as efficacious in ruminants as in non-ruminants, it should be protected from ruminal degradation.
     
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