經(jīng)過(guò)評(píng)估，專(zhuān)家小組認(rèn)為該添加劑對(duì)目標(biāo)物種、消費(fèi)者和環(huán)境是安全的。評(píng)估中的添加劑被認(rèn)為是所有非反芻動(dòng)物物種氨基酸L-組氨酸的有效來(lái)源。為了使補(bǔ)充的L-組氨酸對(duì)反芻動(dòng)物和非反芻動(dòng)物同樣有效，需要防止其在瘤胃中降解。部分原文報(bào)道如下：

 

　　Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-histidine and l-histidine monohydrochloride monohydrate produced with a genetically modified strain of Corynebacterium glutamicum (KCCM 80389) as nutritional and sensory feed additives for all animal species and categories. l-Histidine and l-histidine monohydrochloride monohydrate manufactured by fermentation with C. glutamicum KCCM 80389 do not give rise to any safety concern regarding the genetic modifications of the production strain. No viable cells or DNA of the production strain were detected in the final products. The FEEDAP Panel concluded that the use of l-histidine and l-histidine monohydrochloride monohydrate produced with C. glutamicum KCCM 80389 in feed raises no safety concerns for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the species. The FEEDAP Panel had concerns on the use of l-histidine and l-histidine monohydrochloride monohydrate in water for drinking. The FEEDAP Panel concluded that the use of l-histidine and l-histidine monohydrochloride monohydrate produced by fermentation with C. glutamicum KCCM 80389 in animal nutrition are safe for the consumers of products from animals receiving the additive, and to the environment. Regarding the user safety, the additives are not considered irritant to skin or eyes and are not considered potential skin sensitisers. The additives were regarded as effective sources of the amino acid l-histidine for all non-ruminant species. To be as efficacious in ruminants as in non-ruminants, it should be protected from ruminal degradation.

 

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