應(yīng)歐盟委員會(huì)的要求，歐盟食品安全局食品鏈中污染物專家組（CONTAM）評(píng)估了在食品和飼料中蛇形菌素對(duì)人類和動(dòng)物存在的健康風(fēng)險(xiǎn)。 根據(jù)超過(guò)15,000例的數(shù)據(jù)，最高的急性膳食暴露量和慢性膳食暴露量估計(jì)分別為每天0.8μg DAS/kg體重和0.49μgDAS/ kg體重。家禽，豬和狗的有限信息表明，在目前的飼養(yǎng)方法中，除了肉雞以外，其他動(dòng)物在估計(jì)的DAS暴露水平下的健康風(fēng)險(xiǎn)較低。

 

    部分原文報(bào)道如下：

 

    The main adverse effects after acute and repeated exposure were emesis, with a no‐observed‐adverse‐effect level （NOAEL） of 32 μg DAS/kg body weight （bw）， and haematotoxicity, with a NOAEL of 65 μg DAS/kg bw, respectively. An acute reference dose （ARfD） of 3.2 μg DAS/kg bw and a tolerable daily intake （TDI） of 0.65 μg DAS/kg bw were established. based on over 15,000 occurrence data, the highest acute and chronic dietary exposures were estimated to be 0.8 and 0.49 μg DAS/kg bw per day, respectively, and were not of health concern for humans. The limited information for poultry, pigs and dogs indicated a low risk for these animals at the estimated DAS exposure levels under current feeding practices, with the possible exception of fattening chicken. Assuming similar or lower sensitivity than for poultry, the risk was considered overall low for other farm and companion animal species for which no toxicity data were available. In consideration of the similarities of several trichothecenes and the likelihood of co‐exposure via food and feed, it could be appropriate to perform a cumulative risk assessment for this group of substances.

 

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