食品伙伴網(wǎng)訊  據(jù)歐盟食品安全局（EFSA）消息，歐盟食品安全局食品添加劑和營養(yǎng)源專家組（ANS）重新評估了亞鐵氰化鈉（E 535）（sodium ferrocyanide （E 535）），亞鐵氰化鉀（E 536）（potassium ferrocyanide （E 536）），和亞鐵氰化鈣（E 538）（calcium ferrocyanide （E 538））作為食品添加劑的安全性。

 

    通過評估，歐盟專家小組得出結(jié)論認(rèn)為，亞鐵氰化物在目前的授權(quán)使用水平中不存在安全問題，建議亞鐵氰化鈉，亞鐵氰化鉀，亞鐵氰化鈣作為食品添加劑每日最大攝入量為0.03mg/kg bw。

 

    部分原文報道如下：

 

    The Panel on Food Additives and Nutrient Sources added to Food （ANS） provided a scientific opinion re‐evaluating the safety of sodium ferrocyanide （E 535）， potassium ferrocyanide （E 536）， and evaluating the safety of calcium ferrocyanide （E 538） as food additives. The Panel considered that adequate exposure and toxicity data were available. Ferrocyanides （E 535-538） are solely authorised in two food categories as salt substitutes. To assess the dietary exposure to ferrocyanides （E 535-538） from their use as food additives, the exposure was calculated based on regulatory maximum level exposure assessment scenario （maximum permitted level （MPL）） and the refined exposure assessment scenario. Dietary exposure to ferrocyanides was calculated based on mean and high levels consumption of salts in both the regulatory maximum level and the refined scenario. In the MPL scenario, the exposure to ferrocyanides （E 535-538） from their use as a food additive was up to 0.009 mg/kg body weight （bw） per day in children and adolescents. In the refined estimated exposure scenario, the exposure was up to 0.003 mg/kg bw per day in children and adolescents. Absorption of ferrocyanides is low and there is no accumulation in human. There is no concern with respect to genotoxicity and carcinogenicity. Reproductive studies were not available, but a no observed adverse effect level （NOAEL） of 1,000 mg sodium ferrocyanide/kg bw per day （highest dose tested） was identified from a prenatal developmental toxicity study. The kidney appeared to be the target organ for ferrocyanides toxicity and 4.4 mg sodium ferrocyanide/kg bw per day was identified as the NOAEL for the renal effects in a chronic （2‐year） study in rats. Assuming that the toxicity of this compound is due to the ferrocyanide ion only, the Panel established a group acceptable daily intake （ADI） for sodium, potassium and calcium ferrocyanide of 0.03 mg/kg bw per day expressed as ferrocyanide ion. The Panel concluded that ferrocyanides （E 535-538） are of no safety concern at the current authorised use and use levels.